Nikolsky Sign.

Nikolsky’s sign , used to differentiate between intraepidermal/suprabasal from sub-epidermal blisters→Positive in intraepidermal blisters.

Signs associated with vesiculobullous disorders :

Nikolskys sign

Bulla spread sign/ asboe Hansen sign

False Nikolsky sign/ Sheklakov sign

Pseudo-Nikolsky sign/ Epidermal peeling sign

False Nikolsky’s sign→Positive in subepidermal blisters

Pseudo Nikolsky’s sign positive in:

• Steven-Johnson syndrome
• TEN
• Burns
• Bullous icthyosiform erythroderma.