Omega 3 fatty acid effect on Inflammatory Response.

Omega-3 fatty acids have specific anti-inflammatory effects, including inhibition of NF-B activity, TNF release from hepatic Kupffer cells, as well as leukocyte adhesion and migration.

The anti-inflammatory effects of omega-3 fatty acids on chronic autoimmune diseases such as rheumatoid arthritis, psoriasis, and lupus have been documented in both animals and humans.

In experimental models of sepsis, omega-3 fatty acids inhibit inflammation, ameliorate weight loss, increase small bowel perfusion, and may increase gut barrier protection.

In human studies, omega-3 supplementation is associated with decreased production of TNF, interleukin-1β, and interleukin-6 by endotoxin stimulated monocytes.

In a study of surgical patients, preoperative supplementation with omega-3 fatty acid was associated with reduced need for mechanical ventilation, decreased hospital length of stay, and decreased mortality with a good safety profile.