Factors affecting Minimal Alveolar concentration.

A decrease in MAC is seen in:

Old age
Acute alcohol intoxication
Hypothermia/Hyperthermia
Hypercalcemia
Hypermagnesemia
Hyponatremia.
Anaemia
Hypoxia p02<40
Hypercarbia pCO2 >95
Pregnancy

Drugs:
Local aneasthetics except Cocaine
Opioids
Ketamine
Barbiturates
Benzodiazepines
Verapamil
Lithium
Sympatholytics.
Chronic amphetamine use.

Increased MAC is needed in :
Young age
Chronic alcohol intoxication
Hypernatremia
Acute amphetamine intake
Cocaine
Ephedrine.

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