Factors affecting competitve blockers.

Competitive blockers, are a type of skeletal muscle relaxants which compete with Acetyl choline at the Neuromuscular junction.
Ex. Pancuronium,Vecuronium.

Their interactions are as follows,

Their action is Potentiated by :

General anesthetics especially Isoflurane .

Hypocalcemia, Calcium Channel Blockers (verapamil).

Hypermagnesemia.

Diuretics (by causing hypokalemia).

Drugs like- Diazepam
                    Propranolol
                    Quinidine
                    Aminoglycosides
                    Tetracyclines
                    Clindamycin
                    Lincomycin

Anticholinesterase reverse the action and High dose of glucocorticoids reduces the effect of competitive blockers.